![]() ![]() ![]() Received: DecemAccepted: JanuPublished: February 9, 2018Ĭopyright: © 2018 Lam et al. Anderson, The Francis Crick Institute, UNITED KINGDOM (2018) An integrated strategy for improving contrast, durability, and portability of a Pocket Colposcope for cervical cancer screening and diagnosis. The primary outcome measures were the level of agreement (%) and κ ( kappa) statistic between the standard-of-care colposcope and each Pocket Colposcope (Generation 3 and Generation 4).Ĭitation: Lam CT, Mueller J, Asma B, Asiedu M, Krieger MS, Chitalia R, et al. Corresponding pathology was obtained for all image pairs. ![]() The paired images were blinded by device, randomized, and sent to an expert physician who provided a diagnosis for each image. Specifically, paired images of cervices were collected from the standard-of-care colposcope and either the Generation 3 (n = 24 patients) or the Generation 4 (n = 32 patients) Pocket Colposcopes. A pilot clinical study was conducted to compare the Generation 3 and 4 Pocket Colposcopes to a standard-of-care colposcope (Leisegang Optik 2). ![]() Both systems were characterized with a series of bench tests to assess specular reflection, beam pattern uniformity, and image contrast. The reflector design (including the angle and height of the reflector sidewalls) was optimized through ray-tracing simulations. Cross-polarization (Generation 3 Pocket Colposcope) and a new reflector design (Generation 4 Pocket Colposcope) were used to reduce glare and improve contrast. ![]()
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